Brain to Genetics Mappings of Disorder
Neuro2Gene is a mapping between functional brain networks, as summarized in the neuroscience literature via the NeuroSynth database, and genes, selected with intelligent subset selection using data from the Allen Brain Atlas. We generate 525 gene sets that describe psychologically meaningful terms "brainterms," and use Gene Set Enrichment Analysis to find which of our gene sets are enriched in disorder phenotype. Enrichment means that we have found genes that might be involved with the manifestation of some behavior related to the functional brain maps, a unique mapping from brain, behavior, to gene that could discover new genetic targets for diagnosis and treatment.
Analysis Status Update
Autism
Autism Spectrum Disorder is a child developmental disorder characterized by social, communicative, and cognitive deficits with repetitive behaviors and intense, focused interests.
Schizophrenia
Schizophrenia is a mental disorder that develops later in life involving a breakdown of thought, emotion, behavior, and reality. It leads to faulty perception, inappropriate actions and feelings, and withdrawal from reality and personal relationships
PTSD
Post traumatic stress disorder is a condition of persistent mental and emotional stress occurring as a result of injury or severe psychological shock
Alzheimer's
Alzheimer's disease is a progressive mental deterioration that can occur in middle or old age, due to generalized degeneration of the brain. It is the most common cause of premature senility.
