%PDF-1.6
%
1 0 obj
<>
endobj
2 0 obj
<>stream
Robin Strand, Filip Malmberg, Lars Johansson, Lars Lind, Magnus Sundbom, Håkan Ahlström, Joel Kullberg
A concept for holistic whole body MRI data analysis, Imiomics
www.plosone.org
www.plosone.org
endstream
endobj
3 0 obj
<>/XObject<>>>/CropBox[0 0 612 792]/MediaBox[0 0 612 792]/Parent 13 0 R/Annots 14 0 R/Contents 15 0 R/TrimBox[0 0 612 792]>>
endobj
14 0 obj
[16 0 R 17 0 R 18 0 R 19 0 R 20 0 R 21 0 R 22 0 R 23 0 R 24 0 R 25 0 R 26 0 R 27 0 R 28 0 R 29 0 R 30 0 R 31 0 R 32 0 R 33 0 R 34 0 R 35 0 R 36 0 R 37 0 R 38 0 R 39 0 R]
endobj
16 0 obj
<>/Border[0 0 0]/Dest(Rpone.0169966.ref001)>>
endobj
17 0 obj
<>/Border[0 0 0]/Dest(Rpone.0169966.ref002)>>
endobj
18 0 obj
<>/Border[0 0 0]/Dest(Rpone.0169966.ref003)>>
endobj
19 0 obj
<>/Border[0 0 0]/Dest(Rpone.0169966.ref004)>>
endobj
20 0 obj
<>/Border[0 0 0]/Dest(Rpone.0169966.ref005)>>
endobj
21 0 obj
<>/Border[0 0 0]/Dest(Rpone.0169966.ref006)>>
endobj
22 0 obj
<>/Border[0 0 0]/A 40 0 R>>
endobj
40 0 obj
<>
endobj
23 0 obj
<>/Border[0 0 0]/A 41 0 R>>
endobj
41 0 obj
<>
endobj
24 0 obj
<>/Border[0 0 0]/A 42 0 R>>
endobj
42 0 obj
<>
endobj
25 0 obj
<>/Border[0 0 0]/A 43 0 R>>
endobj
43 0 obj
<>
endobj
26 0 obj
<>/Border[0 0 0]/A 44 0 R>>
endobj
44 0 obj
<>
endobj
27 0 obj
<>/Border[0 0 0]/Dest(Rpone.0169966.ref007)>>
endobj
28 0 obj
<>/Border[0 0 0]/Dest(Rpone.0169966.ref008)>>
endobj
29 0 obj
<>/Border[0 0 0]/Dest(Rpone.0169966.ref009)>>
endobj
30 0 obj
<>/Border[0 0 0]/Dest(Rpone.0169966.ref010)>>
endobj
31 0 obj
<>/Border[0 0 0]/Dest(Rpone.0169966.ref002)>>
endobj
32 0 obj
<>/Border[0 0 0]/Dest(Rpone.0169966.ref011)>>
endobj
33 0 obj
<>/Border[0 0 0]/Dest(Rpone.0169966.ref012)>>
endobj
34 0 obj
<>/Border[0 0 0]/Dest(Rpone.0169966.ref013)>>
endobj
35 0 obj
<>/Border[0 0 0]/Dest(Rpone.0169966.ref011)>>
endobj
36 0 obj
<>/Border[0 0 0]/Dest(Rpone.0169966.ref012)>>
endobj
37 0 obj
<>/Border[0 0 0]/Dest(Rpone.0169966.ref014)>>
endobj
38 0 obj
<>/Border[0 0 0]/Dest(Rpone.0169966.ref015)>>
endobj
39 0 obj
<>/Border[0 0 0]/Dest(Rpone.0169966.ref016)>>
endobj
15 0 obj
[45 0 R 46 0 R 47 0 R 48 0 R 49 0 R 50 0 R 51 0 R 52 0 R 53 0 R 54 0 R 55 0 R 56 0 R 57 0 R 58 0 R 59 0 R 60 0 R 61 0 R 62 0 R]
endobj
45 0 obj
<>stream
q
0.83 0.64 0.02 0 k
386.8724 571.011 m
391.6346 571.011 l
h
f*
393.9024 571.011 m
398.6079 571.011 l
h
f*
400.8756 571.011 m
405.6378 571.011 l
h
f*
407.9055 571.011 m
412.6677 571.011 l
h
f*
414.9354 571.011 m
419.6409 571.011 l
h
f*
421.9087 571.011 m
426.6709 571.011 l
h
f*
293.2157 505.9843 m
393.1087 505.9843 l
h
f*
493.6252 505.9843 m
563.1874 505.9843 l
h
f*
298.8283 493.0016 m
367.3134 493.0016 l
h
f*
225.4677 480.0189 m
314.4756 480.0189 l
h
f*
239.0173 466.9795 m
345.4299 466.9795 l
h
f*
418.4504 428.0315 m
423.2126 428.0315 l
h
f*
466.526 220.0252 m
471.2882 220.0252 l
h
f*
473.5559 220.0252 m
478.3181 220.0252 l
h
f*
480.5291 220.0252 m
490.0535 220.0252 l
h
f*
516.3024 194.0031 m
521.0646 194.0031 l
h
f*
203.4142 142.0157 m
212.9386 142.0157 l
h
f*
215.1496 142.0157 m
224.674 142.0157 l
h
f*
226.9417 142.0157 m
236.4661 142.0157 l
h
f*
388.3465 115.9937 m
397.8709 115.9937 l
h
f*
400.0819 115.9937 m
409.6063 115.9937 l
h
f*
259.0299 103.011 m
268.4976 103.011 l
h
f*
270.7654 103.011 m
280.2898 103.011 l
h
f*
282.5575 103.011 m
292.0819 103.011 l
h
f*
0 g
1 j
1 J
0 w
11.9999 0 0 11.9999 200.0125 706.0535 cm
BT
/F2 1 Tf
1 TL
-0.0033 Tc
0 0 Td
(Introduction)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 200.0125 689.1023 cm
BT
/F6 1 Tf
1 TL
-0.004 Tc
0 0 Td
(Clinical)Tj
3.3165 0 Td
(imaging)Tj
3.4866 0 Td
(modalities)Tj
4.371 0 Td
(such)Tj
2.0579 0 Td
(as)Tj
1.0148 0 Td
(Magnetic)Tj
3.9741 0 Td
(Resonance)Tj
4.5128 0 Td
(Imaging)Tj
3.5603 0 Td
(\(MRI\),)Tj
2.9763 0 Td
(Positron)Tj
3.6397 0 Td
(Emission)Tj
-32.91 -1.3039 Td
(Tomography)Tj
5.4311 0 Td
(\(PET\))Tj
2.6419 0 Td
(and)Tj
1.7291 0 Td
(Computed)Tj
4.5071 0 Td
(Tomography)Tj
5.4368 0 Td
(\(CT\))Tj
2.1713 0 Td
(have)Tj
2.0579 0 Td
(developed)Tj
4.2747 0 Td
(rapidly,)Tj
3.2654 0 Td
(and)Tj
1.7292 0 Td
(it)Tj
0.7823 0 Td
(is)Tj
0.8504 0 Td
(now)Tj
-34.8772 -1.2982 Td
(possible)Tj
3.4072 0 Td
(to)Tj
1.0261 0 Td
(image)Tj
2.6305 0 Td
(the)Tj
1.4684 0 Td
(entire)Tj
2.5511 0 Td
(human)Tj
3.0785 0 Td
(body)Tj
2.2166 0 Td
(in)Tj
1.0375 0 Td
(seconds)Tj
3.3732 0 Td
(or)Tj
1.0942 0 Td
(minutes.)Tj
3.6907 0 Td
(Despite)Tj
3.2484 0 Td
(the)Tj
1.4684 0 Td
(very)Tj
1.9275 0 Td
(strong)Tj
2.7723 0 Td
(devel-)Tj
-34.9906 -1.2983 Td
(opment)Tj
3.3335 0 Td
(on)Tj
1.2756 0 Td
(the)Tj
1.4683 0 Td
(hardware)Tj
3.9968 0 Td
(side,)Tj
2.0239 0 Td
(the)Tj
1.4684 0 Td
(quantitative)Tj
4.9776 0 Td
(image)Tj
2.6305 0 Td
(analysis)Tj
3.3279 0 Td
(methods)Tj
3.685 0 Td
(used)Tj
2.0579 0 Td
(today)Tj
2.4435 0 Td
(do)Tj
1.2529 0 Td
(not)Tj
1.576 0 Td
(uti-)Tj
-35.5178 -1.3039 Td
(lize)Tj
1.5703 0 Td
(the)Tj
1.4684 0 Td
(full)Tj
1.525 0 Td
(potential)Tj
3.7644 0 Td
(of)Tj
1.0148 0 Td
(the)Tj
1.4683 0 Td
(collected)Tj
3.7417 0 Td
(image)Tj
2.6249 0 Td
(data.)Tj
2.143 0 Td
(Whole-body)Tj
5.2327 0 Td
(image)Tj
2.6305 0 Td
(datasets)Tj
3.3619 0 Td
(contain)Tj
3.2428 0 Td
(huge)Tj
-33.7887 -1.2983 Td
(amounts)Tj
3.7133 0 Td
(of)Tj
1.0148 0 Td
(spatially)Tj
3.4809 0 Td
(detailed)Tj
3.3676 0 Td
(morphological,)Tj
6.2815 0 Td
(functional,)Tj
4.5354 0 Td
(and)Tj
1.7348 0 Td
(metabolic)Tj
4.1442 0 Td
(information;)Tj
5.3008 0 Td
(a)Tj
0.6519 0 Td
(whole-)Tj
-34.2252 -1.2982 Td
(body)Tj
2.2166 0 Td
(scan)Tj
1.9843 0 Td
(typically)Tj
3.5659 0 Td
(contains)Tj
3.6057 0 Td
(millions)Tj
3.4809 0 Td
(of)Tj
1.0148 0 Td
(measurements)Tj
6.0321 0 Td
(from)Tj
2.2053 0 Td
(the)Tj
1.474 0 Td
(human)Tj
3.0728 0 Td
(body.)Tj
2.4434 0 Td
(With)Tj
2.2791 0 Td
(current)Tj
-33.3749 -1.304 Td
(state)Tj
2.0352 0 Td
(of)Tj
1.0148 0 Td
(the)Tj
1.4683 0 Td
(art)Tj
1.321 0 Td
(automatic)Tj
4.2292 0 Td
(analysis)Tj
3.3279 0 Td
(methods,)Tj
3.9118 0 Td
(these)Tj
2.2564 0 Td
(detailed)Tj
3.3675 0 Td
(datasets)Tj
3.3562 0 Td
(are)Tj
1.4456 0 Td
(typically)Tj
3.566 0 Td
(heavily)Tj
3.0274 0 Td
(reduced)Tj
-34.3273 -1.2982 Td
(to)Tj
1.0261 0 Td
(a)Tj
0.6519 0 Td
(few)Tj
1.6158 0 Td
(outputs)Tj
3.2598 0 Td
(of)Tj
1.0148 0 Td
(a)Tj
0.652 0 Td
(priori)Tj
2.5228 0 Td
(specified)Tj
3.7134 0 Td
(measurements)Tj
6.032 0 Td
(of)Tj
1.0148 0 Td
(interest)Tj
3.2145 0 Td
(\(e.g.)Tj
1.8992 0 Td
(volumes,)Tj
3.7871 0 Td
(areas,)Tj
2.4661 0 Td
(diameters,)Tj
-32.8703 -1.2983 Td
(average/maximum)Tj
7.7045 0 Td
(tracer)Tj
2.5398 0 Td
(concentrations)Tj
6.1738 0 Td
(etc.\))Tj
1.9276 0 Td
([)Tj
0.83 0.64 0.02 0 k
(1)Tj
0 g
(,)Tj
0.83 0.64 0.02 0 k
(2)Tj
0 g
(,)Tj
0.83 0.64 0.02 0 k
(3)Tj
0 g
(,)Tj
0.83 0.64 0.02 0 k
(4)Tj
0 g
(,)Tj
0.83 0.64 0.02 0 k
(5)Tj
0 g
(,)Tj
0.83 0.64 0.02 0 k
(6)Tj
0 g
(].)Tj
5.1023 0 Td
(This)Tj
1.9842 0 Td
(reduction)Tj
4.1102 0 Td
(is)Tj
0.8448 0 Td
(a)Tj
0.6519 0 Td
(major)Tj
2.6022 0 Td
(limitation)Tj
-0.01 Tc
-33.6413 -1.2983 Td
(in)Tj
1.0204 0 Td
(the)Tj
1.4513 0 Td
(analysis,)Tj
3.498 0 Td
(especially)Tj
3.9571 0 Td
(of)Tj
1.0035 0 Td
(systemic)Tj
3.5829 0 Td
(and)Tj
1.7122 0 Td
(potentially)Tj
4.3936 0 Td
(systemic)Tj
3.583 0 Td
(diseases)Tj
3.3279 0 Td
(where)Tj
2.6248 0 Td
(the)Tj
1.4514 0 Td
(whole)Tj
2.5795 0 Td
(body)Tj
2.1883 0 Td
(is)Tj
-36.3739 -1.3039 Td
(affected,)Tj
3.4979 0 Td
(such)Tj
2.0352 0 Td
(as)Tj
1.0035 0 Td
(cancer)Tj
2.8063 0 Td
(and)Tj
1.7121 0 Td
(diabetes.)Tj
3.634 0 Td
(Furthermore,)Tj
5.5445 0 Td
(statistical)Tj
3.8438 0 Td
(interaction)Tj
4.5411 0 Td
(with)Tj
1.9729 0 Td
(non-imaging)Tj
-30.5913 -1.2982 Td
(data)Tj
1.8878 0 Td
(\(e.g.)Tj
1.8709 0 Td
(hypothesis)Tj
4.405 0 Td
(testing\))Tj
3.1748 0 Td
(can)Tj
1.61 0 Td
(also)Tj
1.7405 0 Td
(only)Tj
1.9559 0 Td
(be)Tj
1.1338 0 Td
(assessed)Tj
3.4243 0 Td
(on)Tj
1.2642 0 Td
(these)Tj
2.228 0 Td
(a)Tj
0.6463 0 Td
(priori)Tj
2.4832 0 Td
(specified)Tj
3.668 0 Td
(measurements.)Tj
-0.004 Tc
-30.2965 -1.2983 Td
(Large)Tj
2.4548 0 Td
(scale)Tj
2.1089 0 Td
(whole-body)Tj
4.9549 0 Td
(MR)Tj
1.7348 0 Td
(data)Tj
1.9106 0 Td
(is)Tj
0.8504 0 Td
(being)Tj
2.4321 0 Td
(collected)Tj
3.736 0 Td
(together)Tj
3.5376 0 Td
(with)Tj
1.9956 0 Td
(non-imaging)Tj
5.4425 0 Td
(data)Tj
1.9162 0 Td
(in)Tj
1.0318 0 Td
(Upp-)Tj
-35.3024 -1.3039 Td
(sala)Tj
1.6951 0 Td
(by)Tj
1.1792 0 Td
(us,)Tj
1.3379 0 Td
(e.g.,)Tj
1.7802 0 Td
(POEM)Tj
2.9877 0 Td
(\()Tj
0.83 0.64 0.02 0 k
(www.medsci.uu.se/po)Tj
9.0878 0 Td
(em)Tj
0 g
(,)Tj
1.6894 0 Td
(PI:)Tj
1.3436 0 Td
(L.)Tj
0.9808 0 Td
(Lind\),)Tj
2.6702 0 Td
(EpiHealth)Tj
4.269 0 Td
(\()Tj
0.83 0.64 0.02 0 k
(www.epihealth.se)Tj
0 g
(,)Tj
-29.0209 -1.2983 Td
(PI:)Tj
1.3436 0 Td
(L.)Tj
0.9807 0 Td
(Lind\))Tj
2.4435 0 Td
(and)Tj
1.7291 0 Td
(UCAN)Tj
3.0444 0 Td
(\()Tj
0.83 0.64 0.02 0 k
(www.u-can.uu.se)Tj
0 g
(,)Tj
7.6365 0 Td
(co-PI:)Tj
2.6249 0 Td
(H.)Tj
1.2132 0 Td
(Ahlstro)Tj
0 Tc
2.5511 0 Td
()Tj
-0.004 Tc
0.4422 0 Td
(m\),)Tj
1.6044 0 Td
(and)Tj
1.7348 0 Td
(elsewhere,)Tj
4.3257 0 Td
(e.g.,)Tj
1.7858 0 Td
(UK)Tj
1.6327 0 Td
(Bio-)Tj
-35.0926 -1.2982 Td
(bank)Tj
2.2053 0 Td
(\()Tj
0.83 0.64 0.02 0 k
(www.ukbiobank.ac.uk)Tj
0 g
(,)Tj
9.6887 0 Td
(up)Tj
1.2643 0 Td
(to)Tj
1.0205 0 Td
(100)Tj
1.6497 0 Td
(000)Tj
1.6441 0 Td
(individuals)Tj
4.6545 0 Td
(will)Tj
1.661 0 Td
(be)Tj
1.1509 0 Td
(scanned\))Tj
3.8268 0 Td
(and)Tj
1.7291 0 Td
(German)Tj
3.5319 0 Td
(Cohort)Tj
-34.0268 -1.304 Td
(Biobank)Tj
3.5602 0 Td
(\()Tj
0.83 0.64 0.02 0 k
(www.nationale-kohorte.de)Tj
0 g
(,)Tj
11.4293 0 Td
(up)Tj
1.2642 0 Td
(to)Tj
1.0261 0 Td
(30)Tj
1.1679 0 Td
(000)Tj
1.6498 0 Td
(volunteers)Tj
4.3823 0 Td
(will)Tj
1.6611 0 Td
(be)Tj
1.1508 0 Td
(scanned\).)Tj
4.0536 0 Td
(However,)Tj
4.0762 0 Td
(tools)Tj
-35.4215 -1.2982 Td
(for)Tj
1.3832 0 Td
(holistic)Tj
3.1181 0 Td
(analysis)Tj
3.3279 0 Td
(of)Tj
1.0148 0 Td
(this)Tj
1.6724 0 Td
(data)Tj
1.9162 0 Td
(have,)Tj
2.2847 0 Td
(to)Tj
1.0262 0 Td
(our)Tj
1.627 0 Td
(knowledge,)Tj
4.7679 0 Td
(not)Tj
1.5704 0 Td
(been)Tj
2.1259 0 Td
(published.)Tj
-24.6385 -1.2983 Td
(Here,)Tj
2.4321 0 Td
(we)Tj
1.3266 0 Td
(present)Tj
3.1691 0 Td
(an)Tj
1.2019 0 Td
(image)Tj
2.6248 0 Td
(analysis)Tj
3.3279 0 Td
(concept,)Tj
3.5886 0 Td
(including)Tj
4.0422 0 Td
(image)Tj
2.6305 0 Td
(registration,)Tj
5.057 0 Td
(which)Tj
2.6476 0 Td
(allows)Tj
2.6985 0 Td
(sta-)Tj
-35.943 -1.2983 Td
(tistical)Tj
2.8119 0 Td
(and)Tj
1.7348 0 Td
(holistic)Tj
3.1181 0 Td
(analysis)Tj
3.3222 0 Td
(of)Tj
1.0148 0 Td
(whole-body)Tj
4.9549 0 Td
(image)Tj
2.6305 0 Td
(data)Tj
1.9162 0 Td
([)Tj
0.83 0.64 0.02 0 k
(7)Tj
0 g
(],)Tj
1.5988 0 Td
(with)Tj
2.0012 0 Td
(example)Tj
3.549 0 Td
(analyses)Tj
3.4809 0 Td
(on)Tj
1.2756 0 Td
(whole-)Tj
-33.4089 -1.3039 Td
(body)Tj
2.2166 0 Td
(image)Tj
2.6306 0 Td
(data)Tj
1.9105 0 Td
(from)Tj
2.2053 0 Td
(the)Tj
1.4684 0 Td
(POEM)Tj
2.9877 0 Td
(cohort,)Tj
3.0841 0 Td
(which)Tj
2.6475 0 Td
(aims)Tj
2.1033 0 Td
(to)Tj
1.0261 0 Td
(investigate)Tj
4.4617 0 Td
(a)Tj
0.652 0 Td
(population-based)Tj
7.1943 0 Td
(sample)Tj
-34.5881 -1.2982 Td
(of)Tj
1.0147 0 Td
(50-year)Tj
3.2032 0 Td
(old)Tj
1.5023 0 Td
(inhabitants)Tj
4.7112 0 Td
(of)Tj
1.0148 0 Td
(the)Tj
1.4683 0 Td
(city)Tj
1.6668 0 Td
(of)Tj
1.0148 0 Td
(Uppsala)Tj
3.4639 0 Td
(invited)Tj
3.0047 0 Td
(in)Tj
1.0375 0 Td
(a)Tj
0.6519 0 Td
(random)Tj
3.4299 0 Td
(manner)Tj
3.3676 0 Td
(to)Tj
1.0261 0 Td
(study)Tj
2.3868 0 Td
(patho-)Tj
-33.9645 -1.2983 Td
(physiological)Tj
5.4424 0 Td
(links)Tj
2.1373 0 Td
(between)Tj
3.532 0 Td
(obesity)Tj
3.0387 0 Td
(and)Tj
1.7291 0 Td
(vascular)Tj
3.4696 0 Td
(dysfunction)Tj
4.972 0 Td
(and)Tj
1.7347 0 Td
(future)Tj
2.6533 0 Td
(cardiovascular)Tj
6.0037 0 Td
(disor-)Tj
-34.7128 -1.3039 Td
(ders,)Tj
2.1259 0 Td
(and)Tj
1.7348 0 Td
(from)Tj
2.2054 0 Td
(a)Tj
0.6519 0 Td
(weight)Tj
2.8857 0 Td
(loss)Tj
1.6951 0 Td
(and)Tj
1.7291 0 Td
(gastric)Tj
2.8403 0 Td
(bypass)Tj
2.8573 0 Td
(study.)Tj
-17.5293 -1.2983 Td
(The)Tj
1.7858 0 Td
(focus)Tj
2.3244 0 Td
(of)Tj
1.0148 0 Td
(this)Tj
1.6781 0 Td
(work)Tj
2.279 0 Td
(is)Tj
0.8447 0 Td
(whole)Tj
2.6079 0 Td
(body)Tj
2.2167 0 Td
(image)Tj
2.6305 0 Td
(registration)Tj
4.8302 0 Td
(with)Tj
2.0013 0 Td
(spatially)Tj
3.4752 0 Td
(varying)Tj
3.2201 0 Td
(tissue)Tj
2.4548 0 Td
(con-)Tj
-34.5597 -1.2983 Td
(straints.)Tj
3.3845 0 Td
(By)Tj
1.2529 0 Td
(utilizing)Tj
3.5206 0 Td
(tissue-specific)Tj
5.7826 0 Td
(elasticity)Tj
3.6907 0 Td
(constraints)Tj
4.6375 0 Td
(in)Tj
1.0375 0 Td
(the)Tj
1.4683 0 Td
(image)Tj
2.6305 0 Td
(registration)Tj
4.8359 0 Td
(under)Tj
2.6135 0 Td
(the)Tj
-34.8545 -1.3039 Td
(assumption)Tj
4.8585 0 Td
(that)Tj
1.7801 0 Td
(bone)Tj
2.2054 0 Td
(is)Tj
0.8504 0 Td
(relatively)Tj
3.8381 0 Td
(rigid)Tj
2.1203 0 Td
(and)Tj
1.7291 0 Td
(has)Tj
1.542 0 Td
(low)Tj
1.6554 0 Td
(inter-subject)Tj
5.2781 0 Td
(variation,)Tj
4.0252 0 Td
(lean)Tj
1.8765 0 Td
(tissue)Tj
2.4548 0 Td
(is)Tj
0.8504 0 Td
(less)Tj
-35.0643 -1.2982 Td
(rigid)Tj
2.1146 0 Td
(and)Tj
1.7348 0 Td
(has)Tj
1.542 0 Td
(higher)Tj
2.8006 0 Td
(inter-individual)Tj
6.548 0 Td
(variation,)Tj
4.0252 0 Td
(and)Tj
1.7348 0 Td
(adipose)Tj
3.2541 0 Td
(tissue)Tj
2.4605 0 Td
(is)Tj
0.8447 0 Td
(highly)Tj
2.7099 0 Td
(elastic)Tj
2.6759 0 Td
(and)Tj
1.7291 0 Td
(has)Tj
1.5421 0 Td
(high)Tj
-35.7163 -1.2983 Td
(inter-subject)Tj
5.278 0 Td
(variation,)Tj
4.0252 0 Td
(all)Tj
1.1452 0 Td
(whole-body)Tj
4.9549 0 Td
(images)Tj
2.9934 0 Td
(are)Tj
1.4456 0 Td
(deformed)Tj
4.1103 0 Td
(by)Tj
1.1792 0 Td
(image)Tj
2.6305 0 Td
(registration)Tj
4.8359 0 Td
(to)Tj
1.0204 0 Td
(a)Tj
0.6577 0 Td
(com-)Tj
-34.2763 -1.3039 Td
(mon)Tj
2.0919 0 Td
(coordinate)Tj
4.5297 0 Td
(system.)Tj
3.1635 0 Td
(The)Tj
1.7801 0 Td
(so-obtained)Tj
4.955 0 Td
(point-to-point)Tj
6.0037 0 Td
(correspondences)Tj
6.9562 0 Td
(are)Tj
1.4513 0 Td
(utilized)Tj
3.1861 0 Td
(in)Tj
1.0375 0 Td
(the)Tj
-35.155 -1.2983 Td
(statistical)Tj
3.9061 0 Td
(analysis.)Tj
-2.7099 -1.2982 Td
(Medical)Tj
3.4355 0 Td
(image)Tj
2.6306 0 Td
(registration)Tj
4.8358 0 Td
(is)Tj
0.8448 0 Td
(often)Tj
2.2847 0 Td
(considered)Tj
4.6034 0 Td
(a)Tj
0.652 0 Td
(challenging)Tj
4.8188 0 Td
(task)Tj
1.8085 0 Td
(due)Tj
1.6951 0 Td
(to,)Tj
1.2529 0 Td
(e.g.,)Tj
1.7859 0 Td
(imperfections)Tj
-31.8442 -1.2983 Td
(in)Tj
1.0318 0 Td
(the)Tj
1.474 0 Td
(image)Tj
2.6248 0 Td
(data)Tj
1.9162 0 Td
(and)Tj
1.7292 0 Td
(varying)Tj
3.2201 0 Td
(morphology.)Tj
5.3631 0 Td
(Therefore,)Tj
4.3937 0 Td
(a)Tj
0.6576 0 Td
(multitude)Tj
4.1556 0 Td
(of)Tj
1.0148 0 Td
(methods)Tj
3.685 0 Td
(designed)Tj
3.7644 0 Td
(for)Tj
-35.0303 -1.3039 Td
(different)Tj
3.6566 0 Td
(body)Tj
2.2167 0 Td
(regions)Tj
3.1634 0 Td
(based)Tj
2.4718 0 Td
(on)Tj
1.2756 0 Td
(different)Tj
3.6567 0 Td
(theoretical)Tj
4.439 0 Td
(foundations,)Tj
5.2611 0 Td
(including)Tj
4.0422 0 Td
(parametric,)Tj
4.8018 0 Td
(non-)Tj
-34.9849 -1.2983 Td
(parametric,)Tj
4.8018 0 Td
(landmark-based)Tj
6.7011 0 Td
(image)Tj
2.6305 0 Td
(registration,)Tj
5.057 0 Td
(etc.)Tj
1.593 0 Td
(with)Tj
1.9956 0 Td
(different)Tj
3.6567 0 Td
(transformation)Tj
6.2759 0 Td
(models,)Tj
-32.7116 -1.2983 Td
(matching)Tj
4.0024 0 Td
(criteria)Tj
3.0785 0 Td
(and)Tj
1.7291 0 Td
(optimization)Tj
5.3631 0 Td
(methods)Tj
3.685 0 Td
(have)Tj
2.0579 0 Td
(been)Tj
2.126 0 Td
(developed)Tj
4.269 0 Td
([)Tj
0.83 0.64 0.02 0 k
(8)Tj
0 g
(,)Tj
0.83 0.64 0.02 0 k
(9)Tj
0 g
(,)Tj
0.83 0.64 0.02 0 k
(10)Tj
0 g
(].)Tj
-25.1148 -1.3039 Td
(Whole-body)Tj
5.2384 0 Td
(water-fat)Tj
3.804 0 Td
(MRI)Tj
2.075 0 Td
(image)Tj
2.6248 0 Td
(registration)Tj
4.8359 0 Td
(methods)Tj
3.685 0 Td
(related)Tj
2.9424 0 Td
(to)Tj
1.0261 0 Td
(the)Tj
1.4683 0 Td
(one)Tj
1.7008 0 Td
(presented)Tj
4.1159 0 Td
(here)Tj
-34.7128 -1.2982 Td
(includes)Tj
3.5432 0 Td
(the)Tj
1.4684 0 Td
(method)Tj
3.3278 0 Td
(based)Tj
2.4718 0 Td
(on)Tj
1.2756 0 Td
(so-called)Tj
3.736 0 Td
(morphons)Tj
4.3824 0 Td
(presented)Tj
4.1159 0 Td
(by)Tj
1.1792 0 Td
(Karlsson)Tj
3.7247 0 Td
(et)Tj
0.9411 0 Td
(al.)Tj
1.1281 0 Td
([)Tj
0.83 0.64 0.02 0 k
(2)Tj
0 g
(].)Tj
1.5988 0 Td
(They)Tj
-32.893 -1.2983 Td
(use)Tj
1.5306 0 Td
(the)Tj
1.4684 0 Td
(registration)Tj
4.8359 0 Td
(method)Tj
3.3221 0 Td
(together)Tj
3.5377 0 Td
(with)Tj
1.9955 0 Td
(a)Tj
0.652 0 Td
(multi-atlas)Tj
4.5014 0 Td
(approach)Tj
3.9571 0 Td
(to)Tj
1.0205 0 Td
(achieve)Tj
3.1748 0 Td
(a)Tj
0.6576 0 Td
(stable)Tj
2.4888 0 Td
(fat)Tj
1.2416 0 Td
(and)Tj
-34.384 -1.3039 Td
(muscle)Tj
3.0217 0 Td
(segmentation)Tj
5.6125 0 Td
(and)Tj
1.7291 0 Td
(quantification.)Tj
6.0662 0 Td
(Methods)Tj
3.753 0 Td
(for)Tj
1.389 0 Td
(spatially)Tj
3.4752 0 Td
(varying)Tj
3.2202 0 Td
(elasticity)Tj
3.6906 0 Td
(constraints)Tj
4.6375 0 Td
(in)Tj
-36.595 -1.2983 Td
(image)Tj
2.6305 0 Td
(registration)Tj
4.8302 0 Td
(are)Tj
1.4513 0 Td
(often)Tj
2.2847 0 Td
(based)Tj
2.4718 0 Td
(on)Tj
1.2756 0 Td
(putting)Tj
3.1408 0 Td
(constraints)Tj
4.6374 0 Td
(on)Tj
1.2756 0 Td
(the)Tj
1.474 0 Td
(parametric)Tj
4.5751 0 Td
(deformation)Tj
5.2157 0 Td
(field)Tj
-35.2627 -1.2983 Td
([)Tj
0.83 0.64 0.02 0 k
(11)Tj
0 g
(,)Tj
0.83 0.64 0.02 0 k
(12)Tj
0 g
(,)Tj
0.83 0.64 0.02 0 k
(13)Tj
0 g
(])Tj
4.2009 0 Td
(and,)Tj
1.9559 0 Td
(for)Tj
1.3889 0 Td
(CT)Tj
1.4967 0 Td
(image)Tj
2.6249 0 Td
(data,)Tj
2.143 0 Td
(on)Tj
1.2755 0 Td
(the)Tj
1.4684 0 Td
(assumption)Tj
4.8585 0 Td
(that)Tj
1.7802 0 Td
(tissue)Tj
2.4604 0 Td
(with)Tj
1.9956 0 Td
(low)Tj
1.6554 0 Td
(Hounsfield)Tj
4.6885 0 Td
(units)Tj
2.2224 0 Td
(are)Tj
-36.2152 -1.3039 Td
(more)Tj
2.3414 0 Td
(elastic)Tj
2.6702 0 Td
(than)Tj
2.0296 0 Td
(tissue)Tj
2.4604 0 Td
(with)Tj
1.9956 0 Td
(high)Tj
2.0069 0 Td
(Hounsfield)Tj
4.6885 0 Td
(units.)Tj
2.4434 0 Td
(The)Tj
1.7859 0 Td
(latter)Tj
2.2903 0 Td
(idea)Tj
1.8709 0 Td
(has)Tj
1.542 0 Td
(been)Tj
2.126 0 Td
(used)Tj
2.0579 0 Td
(in,)Tj
1.2643 0 Td
(e.g.,)Tj
-33.5733 -1.2982 Td
(deformable)Tj
4.7678 0 Td
(registration)Tj
4.8302 0 Td
(of)Tj
1.0148 0 Td
(thorax)Tj
2.8233 0 Td
(CT)Tj
1.4967 0 Td
(volumes)Tj
3.5603 0 Td
([)Tj
0.83 0.64 0.02 0 k
(11)Tj
0 g
(,)Tj
0.83 0.64 0.02 0 k
(12)Tj
0 g
(])Tj
3.0273 0 Td
(and)Tj
1.7292 0 Td
(registration)Tj
4.8302 0 Td
(of)Tj
1.0148 0 Td
(whole)Tj
2.6135 0 Td
(body)Tj
2.2167 0 Td
(mice)Tj
/F11 1 Tf
-33.9248 -1.2983 Td
[()]TJ
/F6 1 Tf
(CT)Tj
2.0012 0 Td
(volumes)Tj
3.5603 0 Td
([)Tj
0.83 0.64 0.02 0 k
(14)Tj
0 g
(,)Tj
0.83 0.64 0.02 0 k
(15)Tj
0 g
(,)Tj
0.83 0.64 0.02 0 k
(16)Tj
0 g
(],)Tj
4.4277 0 Td
(where)Tj
2.6532 0 Td
(the)Tj
1.4683 0 Td
(high)Tj
2.0069 0 Td
(contrast)Tj
3.464 0 Td
(between)Tj
3.5262 0 Td
(bone)Tj
2.2054 0 Td
(and)Tj
1.7291 0 Td
(other)Tj
2.3471 0 Td
(tissue)Tj
2.4604 0 Td
(is)Tj
0.8504 0 Td
(utilized)Tj
3.1918 0 Td
(by)Tj
-35.892 -1.2983 Td
(registering)Tj
4.4787 0 Td
(segmented)Tj
4.5127 0 Td
(bone)Tj
2.2053 0 Td
(as)Tj
1.0148 0 Td
(an)Tj
1.2019 0 Td
(initial)Tj
2.5512 0 Td
(step.)Tj
ET
Q
q
1 j
1 J
0 w
576 737.1 m
36 737.1 l
36 737.6 l
576 737.6 l
f*
36 741.2598 107.1496 23.6976 re
W* n
q
107.0929 0 0 23.6409 36 741.3165 cm
q
/I0 Do
Q
Q
Q
q
0 0 612 792 re
W* n
1 j
1 J
0 w
7.9999 0 0 7.9999 544.8755 745.7952 cm
BT
/F0 1 Tf
1 TL
-0.005 Tc
0 0 Td
(Imiomics)Tj
ET
Q
q
1 j
1 J
0 w
36 48.0002 m
576 48.0002 l
576 47.5002 l
36 47.5002 l
f*
7.9999 0 0 7.9999 36 36 cm
BT
/F0 1 Tf
1 TL
-0.005 Tc
0 0 Td
(PLOS)Tj
2.8559 0 Td
(ONE)Tj
2.3669 0 Td
(|)Tj
0.4748 0 Td
(DOI:10.137)Tj
5.0387 0 Td
(1/journal.po)Tj
5.1236 0 Td
(ne.0169)Tj
3.5434 0 Td
(966)Tj
2.6362 0 Td
(February)Tj
4.1599 0 Td
(27,)Tj
1.5874 0 Td
(2017)Tj
37.3538 0 Td
(2)Tj
0.7654 0 Td
(/)Tj
0.496 0 Td
(17)Tj
/F8 1 Tf
-0.025 Tc
-66.402 84.0904 Td
(Funding:)Tj
/F9 1 Tf
3.5716 0 Td
(The)Tj
1.5874 0 Td
(authors)Tj
3.0473 0 Td
(received)Tj
3.3024 0 Td
(no)Tj
1.1622 0 Td
(specific)Tj
3.026 0 Td
(funding)Tj
-15.6969 -1.3748 Td
(for)Tj
1.2543 0 Td
(this)Tj
1.5661 0 Td
(work.)Tj
/F8 1 Tf
-2.8204 -2.126 Td
(Competing)Tj
4.3795 0 Td
(interests)Tj
3.3307 0 Td
(:)Tj
/F9 1 Tf
0.4819 0 Td
(I)Tj
0.4748 0 Td
(have)Tj
1.956 0 Td
(read)Tj
1.8425 0 Td
(the)Tj
1.3677 0 Td
(journal's)Tj
-13.8331 -1.3749 Td
(policy)Tj
2.3952 0 Td
(and)Tj
1.5875 0 Td
(the)Tj
1.3748 0 Td
(authors)Tj
3.0402 0 Td
(of)Tj
0.9496 0 Td
(this)Tj
1.5661 0 Td
(manuscript)Tj
4.415 0 Td
(have)Tj
1.9559 0 Td
(the)Tj
-17.2843 -1.3748 Td
(following)Tj
3.5858 0 Td
(competing)Tj
4.1599 0 Td
(interests:)Tj
3.6142 0 Td
(A)Tj
0.7441 0 Td
(patent)Tj
2.5228 0 Td
(application)Tj
3.9898 0 Td
(,)Tj
-18.6166 -1.3748 Td
(P1318PC0)Tj
3.9401 0 Td
(0,)Tj
0.9213 0 Td
(by)Tj
1.1126 0 Td
(Robin)Tj
2.4237 0 Td
(Strand,)Tj
2.8984 0 Td
(Joel)Tj
1.7291 0 Td
(Kullberg)Tj
3.2812 0 Td
(and)Tj
-16.3064 -1.3748 Td
(H)Tj
/F10 1 Tf
[( n)]TJ
/F9 1 Tf
(kan)Tj
2.5441 0 Td
(Ahlstro)Tj
0 Tc
2.2606 0 Td
()Tj
-0.025 Tc
0.3898 0 Td
(m)Tj
0.9709 0 Td
(describing)Tj
4.0748 0 Td
(the)Tj
1.3677 0 Td
(presented)Tj
3.8906 0 Td
(image)Tj
-15.4985 -1.3748 Td
(registrati)Tj
3.2456 0 Td
(on)Tj
1.1693 0 Td
(method)Tj
3.0686 0 Td
(is)Tj
0.8362 0 Td
(currently)Tj
3.4937 0 Td
(under)Tj
2.3741 0 Td
(review.)Tj
2.8488 0 Td
(Lars)Tj
-17.0363 -1.3748 Td
(Johansson,)Tj
4.5 0 Td
(Joel)Tj
1.7291 0 Td
(Kullberg)Tj
3.2812 0 Td
(and)Tj
1.5874 0 Td
(H)Tj
/F10 1 Tf
[( n)]TJ
/F9 1 Tf
(kan)Tj
2.5441 0 Td
(Ahlstro)Tj
0 Tc
2.2606 0 Td
()Tj
-0.025 Tc
0.3898 0 Td
(m)Tj
0.9709 0 Td
(are)Tj
-17.2631 -1.3748 Td
(cofounder)Tj
3.7701 0 Td
(s,)Tj
0.8716 0 Td
(co-owne)Tj
3.2032 0 Td
(rs)Tj
0.9496 0 Td
(of)Tj
0.9496 0 Td
(and)Tj
1.5874 0 Td
(employed)Tj
3.8552 0 Td
(at)Tj
0.8929 0 Td
(Antaros)Tj
-16.0796 -1.3749 Td
(Medical)Tj
3.0968 0 Td
(AB,)Tj
1.4953 0 Td
(BioVenture)Tj
4.2874 0 Td
(Hub,)Tj
1.9843 0 Td
(Mo)Tj
0 Tc
0.8362 0 Td
()Tj
-0.025 Tc
0.3898 0 Td
(lndal,)Tj
2.1969 0 Td
(Sweden.)Tj
-14.2867 -1.3748 Td
(Antaros)Tj
3.0968 0 Td
(has)Tj
1.5378 0 Td
(not)Tj
1.4245 0 Td
(been)Tj
2.0055 0 Td
(involved)Tj
3.2953 0 Td
(in)Tj
0.8858 0 Td
(the)Tj
1.3677 0 Td
(developm)Tj
3.6284 0 Td
(ent)Tj
-17.2418 -1.3748 Td
(of)Tj
0.9496 0 Td
(Imiomics.)Tj
3.9118 0 Td
(Howev)Tj
2.537 0 Td
(er,)Tj
1.1764 0 Td
(we)Tj
1.2827 0 Td
(are)Tj
1.3677 0 Td
(currently)Tj
-11.2252 -1.3748 Td
(considerin)Tj
3.848 0 Td
(g)Tj
0.6945 0 Td
(collaborating)Tj
4.9961 0 Td
(on)Tj
1.1693 0 Td
(the)Tj
1.3677 0 Td
(Imiomics)Tj
3.6851 0 Td
(concept)Tj
-15.7607 -1.3748 Td
(with)Tj
1.7787 0 Td
(Antaros)Tj
3.0969 0 Td
(Medical)Tj
3.1039 0 Td
(AB.)Tj
1.4953 0 Td
(This)Tj
1.7788 0 Td
(does)Tj
2.0055 0 Td
(not)Tj
1.4244 0 Td
(alter)Tj
1.8213 0 Td
(our)Tj
-16.5048 -1.3748 Td
(adherence)Tj
4.0535 0 Td
(to)Tj
0.9496 0 Td
(PLOS)Tj
2.3316 0 Td
(ONE)Tj
1.8708 0 Td
(policies)Tj
3.0119 0 Td
(on)Tj
1.1622 0 Td
(sharing)Tj
2.9835 0 Td
(data)Tj
-16.3631 -1.3748 Td
(and)Tj
ET
endstream
endobj
46 0 obj
<>stream
endstream
endobj
47 0 obj
<>stream
endstream
endobj
48 0 obj
<>stream
endstream
endobj
49 0 obj
<>stream
endstream
endobj
50 0 obj
<>stream
endstream
endobj
51 0 obj
<>stream
endstream
endobj
52 0 obj
<>stream
endstream
endobj
53 0 obj
<>stream
endstream
endobj
54 0 obj
<>stream
endstream
endobj
55 0 obj
<>stream
endstream
endobj
56 0 obj
<>stream
endstream
endobj
57 0 obj
<>stream
endstream
endobj
58 0 obj
<>stream
endstream
endobj
59 0 obj
<>stream
endstream
endobj
60 0 obj
<>stream
endstream
endobj
61 0 obj
<>stream
endstream
endobj
62 0 obj
<>stream
BT
1.5874 61.3422 Td
(materials.)Tj
ET
Q
endstream
endobj
63 0 obj
<>/XObject<>>>/CropBox[0 0 612 792]/MediaBox[0 0 612 792]/Parent 13 0 R/Annots 66 0 R/Contents 67 0 R/TrimBox[0 0 612 792]>>
endobj
65 0 obj
<>
endobj
68 0 obj
<>stream
/CIDInit/ProcSet findresource begin
12 dict begin begincmap
/CMapName/Adobe-Identity-UCS def
/CIDSystemInfo<>def
/CMapType 2 def
1 begincodespacerange
<0000>
endcodespacerange
1 beginbfchar
<00EF><0394>
endbfchar
endcmap
CMapName currentdict /CMap defineresource pop end end
endstream
endobj
69 0 obj
<>/FontDescriptor 70 0 R/DW 250/W[239[603]]>>
endobj
70 0 obj
<>
endobj
71 0 obj
<>stream
cvt f6 fpgm2Msf bglyfcW Dhead= 6hhea1 $hmtx&O